Skip to Main content Skip to Navigation
Journal articles

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

Alexandre Prola 1 Jordan Blondelle 1 Aymeline Vandestienne 1 Jérôme Piquereau 2 Raphaël Denis 3 Stéphane Guyot 4 Hadrien Chauvin 1 Arnaud Mourier 5 Marie Maurer 1 Céline Henry 6 Nahed Khadhraoui 1 Cindy Gallerne 1 Thibaut Molinié 5 Guillaume Courtin 1 Laurent Guillaud 1 Mélanie Gressette 2 Audrey Solgadi 7 Florent Dumont 7 Julien Castel 3 Julien Ternacle 1 Jean Demarquoy 8 Alexandra Malgoyre 9 Nathalie Koulmann 9, 10 Geneviève Derumeaux 1 Marie-France Giraud 5, 6 Frederic Joubert 9 Vladimir Veksler 11 Serge Luquet 3 Frédéric Relaix 1 Laurent Tiret 1 Fanny Pilot-Storck 1
1 IMRB - Institut Mondor de Recherche Biomédicale
2 CARPAT - Signalisation et physiopathologie cardiovasculaire
3 BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative
4 PMB - Procédés Microbiologiques et Biotechnologiques
PAM - Procédés Alimentaires et Microbiologiques, PAM - Procédés Alimentaires et Microbiologiques [Dijon]
5 IBGC - Institut de biochimie et génétique cellulaires
6 PAPPSO - Plateforme d'Analyse Protéomique de Paris Sud Ouest
7 IPSIT - Ingénierie et Plateformes au Service de l'Innovation Thérapeutique
8 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
9 LBEPS - Laboratoire de Biologie de l'Exercice pour la Performance et la Santé
10 EVDG - École du Val de Grâce
11 Université Paris-Saclay, Faculté de Pharmacie, 92290 Châtenay-Malabry, France
Abstract : Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and protection against high-fat diet–induced obesity. Mechanistically, muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of the inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and adenosine 5′-triphosphate (ATP) synthase, which was restored by cardiolipin enrichment. Our study reveals that selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.
Document type :
Journal articles
Complete list of metadata
https://hal-agrosup-dijon.archives-ouvertes.fr/hal-03105418
Contributor : Admin Agrosupdijon <>
Submitted on : Tuesday, January 26, 2021 - 9:53:40 AM
Last modification on : Saturday, July 3, 2021 - 12:26:19 AM
Long-term archiving on: : Tuesday, April 27, 2021 - 6:19:05 PM

File

Vignette du document
eabd6322.full.pdf
Publication funded by an institution

Identifiers

Collections

INSERM | UP-SCIENCES | UNIV-PARIS | LBEPS | AGROSUP-PAM | AGROSUP-DIJON | PAM | SSA | UNIV-BOURGOGNE | UPEC-UPEM | CNRS | UNIV-EVRY | IMRB | UPEC | GS-SPORT-HUMAN-MOVEMENT | GS-HEALTH-DRUG-SCIENCES

Citation

Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jérôme Piquereau, Raphaël Denis, et al.. Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle. Science Advances , American Association for the Advancement of Science (AAAS), 2021, 7 (1), pp.eabd6322. ⟨10.1126/sciadv.abd6322⟩. ⟨hal-03105418⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

227

Files downloads

175