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Output of liver fatty acid-binding protein (L-FABP) in bile.

Abstract : Liver fatty acid-binding protein (L-FABP) is a small cytoplasmic molecule highly expressed in the liver. Since L-FABP exhibits affinities for several biliary components, its presence in bile was explored by Western blotting and competitive ELISA in various mammalian species. A L-FABP-like immunoreactivity was consistently found in both hepatic and gallbladder bile. A close molecular identity between this 14 kDa biliary protein and the purified L-FABP was assessed by immunological analyses and high performance capillary electrophoresis. Pharmacological induction of hepatic L-FABP biosynthesis led to a similar increase in biliary L-FABP levels showing a close relationships between the cytosolic and biliary contents of this protein. Finally, a correlation between the presence of L-FABP in bile and both bile flow and bile acid release was found. These data suggest an output of L-FABP in bile in normal conditions which might be coupled with the physiological release of biliary components.
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Submitted on : Thursday, March 21, 2019 - 8:59:52 AM
Last modification on : Wednesday, December 9, 2020 - 10:32:02 AM


  • HAL Id : hal-02074903, version 1
  • PUBMED : 9989289



Laurent Foucaud, Joël Grillasca, Isabelle Niot, Nicole Domingo, Huguette Lafont, et al.. Output of liver fatty acid-binding protein (L-FABP) in bile.. BBA - Biochimica et Biophysica Acta, Elsevier, 1999, 1436 (3), pp.593-599. ⟨hal-02074903⟩



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