Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging
Guillaume Thomas
1
Julien Boudon
1
Lionel Maurizi
1
Mathieu Moreau
2
Paul Walker
3
Isabelle Séverin
4
Alexandra Oudot
5
Christine Goze
2
Sophie Poty
2
Jean-Marc Vrigneaud
5
Frédéric Demoisson
1
Franck Denat
2
François Brunotte
5
Nadine Millot
1
Guillaume Thomas 1
Author
Julien Boudon 1
Mail :
Author IdHAL : julien-boudon ResearcherId : http://www.researcherid.com/rid/D-4684-2011 ORCID : https://orcid.org/0000-0002-2500-5030
Lionel Maurizi 1
Mail :
Author IdHAL : lionel-maurizi ResearcherId : http://www.researcherid.com/rid/E-3606-2016 ORCID : https://orcid.org/0000-0002-6346-7623
Mathieu Moreau 2
Mail :
Author IdHAL : mathieu-moreau ResearcherId : http://www.researcherid.com/rid/A-3044-2013
Paul Walker 3
Mail :
Author
Isabelle Séverin 4
Mail :
Author IdHAL : isabelle-severin ResearcherId : http://www.researcherid.com/rid/15840579800 IdRef : https://www.idref.fr/067289991 ORCID : https://orcid.org/0000-0002-8103-3896
Alexandra Oudot 5
Author
Christine Goze 2
Mail :
Author
Sophie Poty 2
Author
Jean-Marc Vrigneaud 5
Author
Frédéric Demoisson 1
Author
Franck Denat 2
Mail :
Author
François Brunotte 5
Author
Nadine Millot 1
Mail :
Author
1
LICB - Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (Université de Bourgogne - 9 avenue Alain Savary - BP 47870 - 21078 Dijon Cedex - France)
- UTBM - Université de Technologie de Belfort-Montbeliard (France)
- UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR CNRS 6303 (France)
2
ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (Université de Bourgogne - 9 Avenue Alain Savary - BP 47870 - 21078 Dijon Cedex - France)
- UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6302 (France)
3
CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
4
NUTOX - Equipe NuTox (LNC - U1231) (Université de Bourgogne - Faculté de médecine - 7, Bld Jeanne d'Arc - BP 87900 - 21079 DIJON CEDEX - France)
- LNC - Lipides - Nutrition - Cancer [Dijon - U1231] (Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex - France)
- UB - Université de Bourgogne (Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1231 (101, rue de Tolbiac, 75013 Paris - France)
- AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement : UMR_S 866 (26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex - France)
5
CGFL - Plateforme d'imagerie préclinique [Centre Georges-François Leclerc] (1 Rue du Professeur Marion, 21000 Dijon - France)
- CRLCC - CGFL - Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (1 Rue du Professeur Marion, 21000 Dijon - France)
Abstract : Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.
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https://hal-agrosup-dijon.archives-ouvertes.fr/hal-02068644
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Submitted on : Friday, March 15, 2019 - 10:27:02 AM
Last modification on : Monday, October 21, 2019 - 3:35:36 PM
Contributor : Administrateur Agrosupdijon <>
Submitted on : Friday, March 15, 2019 - 10:27:02 AM
Last modification on : Monday, October 21, 2019 - 3:35:36 PM
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- HAL Id : hal-02068644, version 1
- DOI : 10.1021/acsomega.8b03283
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AGROSUP-DIJON | AGROSUP-LNC | CNRS | UNIV-BM | UNIV-BOURGOGNE | CGFL | UNIV-BM-THESE | FNCLCC | LNC-UMR866 | LNC-NUTOX | INC-CNRS | ICMUB
Citation
Guillaume Thomas, Julien Boudon, Lionel Maurizi, Mathieu Moreau, Paul Walker, et al.. Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega, ACS Publications, 2019, 4 (2), pp.2637-2648. ⟨10.1021/acsomega.8b03283⟩. ⟨hal-02068644⟩
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