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Journal articles
Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging
Abstract : Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.
https://hal-agrosup-dijon.archives-ouvertes.fr/hal-02068644
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Submitted on : Monday, March 8, 2021 - 5:06:35 PM
Last modification on : Tuesday, January 4, 2022 - 6:10:40 AM
Long-term archiving on: : Wednesday, June 9, 2021 - 7:26:22 PM
Contributor : Admin Agrosupdijon Connect in order to contact the contributor
Submitted on : Monday, March 8, 2021 - 5:06:35 PM
Last modification on : Tuesday, January 4, 2022 - 6:10:40 AM
Long-term archiving on: : Wednesday, June 9, 2021 - 7:26:22 PM
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2019 acsomega.8b03283.pdf
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