Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Guillaume Thomas 1 Julien Boudon 1 Lionel Maurizi 1 Mathieu Moreau 2 Paul Walker 3 Isabelle Séverin 4 Alexandra Oudot 5 Christine Goze 2 Sophie Poty 2 Jean-Marc Vrigneaud 5 Frédéric Demoisson 1 Franck Denat 2 François Brunotte 5 Nadine Millot 1
1 LICB - Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon]
2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
3 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
4 NUTOX - Equipe NuTox (LNC - U1231)
LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
5 CGFL - Plateforme d'imagerie préclinique [Centre Georges-François Leclerc]
Abstract : Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.
Keywords : Imaging agents Nanoparticles Nanostructures Tomography
Document type :
Journal articles
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https://hal-agrosup-dijon.archives-ouvertes.fr/hal-02068644
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Submitted on : Friday, March 15, 2019 - 10:27:02 AM
Last modification on : Monday, October 21, 2019 - 3:35:36 PM

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AGROSUP-DIJON | AGROSUP-LNC | CNRS | UNIV-BM | UNIV-BOURGOGNE | CGFL | UNIV-BM-THESE | FNCLCC | LNC-UMR866 | LNC-NUTOX | INC-CNRS | ICMUB

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Guillaume Thomas, Julien Boudon, Lionel Maurizi, Mathieu Moreau, Paul Walker, et al.. Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega, ACS Publications, 2019, 4 (2), pp.2637-2648. ⟨10.1021/acsomega.8b03283⟩. ⟨hal-02068644⟩

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