CLA, “new nutrients”?

Abstract : Conjugated linoleic acid (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with commercial isomeric mixtures sold as dietary supplements leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this antiobesity effect.The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review. In Human, the effect of a commercial CLA mixture on fat stores is anecdotic. However, a significant impairment of insulin sensitivity has been reported in subjects receiving purified t10,c12CLA. This finding raises the question of safety of dietary supplements containing high quantity of this isomer that are widely promoted as non prescription anti-obesity agents
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Submitted on : Friday, November 9, 2018 - 10:42:38 AM
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Philippe Besnard, Hélène Poirier, Isabelle Niot, Michèle Guerre-Millo. CLA, “new nutrients”?. Oléagineux, Corps Gras, Lipides, John Libbey Eurotext, 2005, 12 (1), pp.51 - 55. ⟨10.1051/ocl.2005.0051⟩. ⟨hal-01917150⟩

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