HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

CLA et syndrome lipoatrophique chez la souris

Abstract : Conjugated linoleic acid (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with a commercial mixture containing c9,t11-CLA and t10,c12-CLA in equimolar quantity leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
Document type :
Journal articles
Complete list of metadata

Contributor : Kevin Oudard Connect in order to contact the contributor
Submitted on : Friday, November 9, 2018 - 10:33:43 AM
Last modification on : Wednesday, December 9, 2020 - 10:32:02 AM

Links full text



Philippe Besnard, Hélène Poirier, Isabelle Niot, Michèle Guerre-Millo. CLA et syndrome lipoatrophique chez la souris. Oléagineux, Corps Gras, Lipides, John Libbey Eurotext, 2005, 12 (1), pp.51 - 55. ⟨10.1051/ocl.2005.0051⟩. ⟨hal-01917143⟩



Record views