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Journal articles

CLA et syndrome lipoatrophique chez la souris

Abstract : Conjugated linoleic acid (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with a commercial mixture containing c9,t11-CLA and t10,c12-CLA in equimolar quantity leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
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Submitted on : Friday, November 9, 2018 - 10:33:43 AM
Last modification on : Wednesday, December 9, 2020 - 10:32:02 AM

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Philippe Besnard, Hélène Poirier, Isabelle Niot, Michèle Guerre-Millo. CLA et syndrome lipoatrophique chez la souris. Oléagineux, Corps Gras, Lipides, John Libbey Eurotext, 2005, 12 (1), pp.51 - 55. ⟨10.1051/ocl.2005.0051⟩. ⟨hal-01917143⟩

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