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CLA and mouse lipoatrophic syndrome

Abstract : Conjugated linoleic add (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with a commercial mixture containing c9,t11-CLA and t10,c12-CLA in equimolar quantity leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
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Philippe Besnard, Hélène Poirier, Isabelle Niot, Michèle Guerre-Millo. CLA and mouse lipoatrophic syndrome. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2005, 1735 (1), pp.41 - 49. ⟨10.1016/j.bbalip.2005.05.002⟩. ⟨hal-01917127⟩



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