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Journal articles

Fatty acid regulation of fatty acid-binding protein expression in the small intestine

Abstract : The effects of dietary oil intake and fatty acid infusions on the expression of intestinal and liver fatty acid-binding proteins (I-FABP and L-FABP, respectively) were investigated in the small intestine of mice. A daily force-feeding for 7 days with 0.2 ml sunflower oil specifically increased L-FABP mRNA and protein levels in duodenum and proximal jejunum. This upregulation was mediated in time- and dose-dependent manners by a minute quantity of linoleic acid, the main fatty acid found in sunflower oil. The L-FABP induction was only found with long-chain fatty acids, with the nonmetabolizable, substituted fatty acid alpha-bromopalmitate being far more active. A hormonally mediated effect is unlikely because long-chain fatty acids induced L-FABP mRNA in the Caco-2 cell line cultured in serum-free medium. Therefore, long-chain fatty acids are strong inducers of L-FABP gene expression in the small intestine. In contrast to data found in the rat, I-FABP gene expression appears to be unaffected by a lipid-enriched diet in the mouse.
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Hélène Poirier, Isabelle Niot, Degrace Pascal, Marie-Claude Monnot, A. Bernard, et al.. Fatty acid regulation of fatty acid-binding protein expression in the small intestine. AJP - Gastrointestinal and Liver Physiology, American Physiological Society, 1997, 273 (2), pp.G289 - G295. ⟨10.1152/ajpgi.1997.273.2.G289⟩. ⟨hal-01915874⟩



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