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Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse

Hélène Poirier 1 Isabelle Niot 1 L. Clement 1 Michèle Guerre-Millo 2 Philippe Besnard 1
1 NUTox - Physiologie de la Nutrition et Toxicologie (NUTox) (U866, Lipides et nutrition, équipe 7)
LNC - Lipides - Nutrition - Cancer (U866)
2 Génie Biomédical et Diabète Sucré
Abstract : Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
Keywords : Conjugated linoleic acid Lipoatrophy Insulin resistance β-cell hyperplasia Liver steatosis
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Journal articles
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https://hal-agrosup-dijon.archives-ouvertes.fr/hal-01915834
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Submitted on : Thursday, November 8, 2018 - 9:33:57 AM
Last modification on : Wednesday, December 9, 2020 - 10:32:02 AM

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AGROSUP-DIJON | AGROSUP-LNC | UNIV-BOURGOGNE | LNC-UMR866 | UPMC | UMR866-EQUIPE7 | SORBONNE-UNIVERSITE | SU-MEDECINE

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Hélène Poirier, Isabelle Niot, L. Clement, Michèle Guerre-Millo, Philippe Besnard. Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse. Biochimie, Elsevier, 2005, 87 (1), pp.73 - 79. ⟨10.1016/j.biochi.2004.11.006⟩. ⟨hal-01915834⟩

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